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Multiple organ failure as onset of mediterranean spotted fever: A review based on a case

  • Autori: Mansueto P.; Seidita A.; Bongiovi A.; Catalano T.; Pirrone G.; Cusimano C.; D'Alcamo A.; Carroccio A.
  • Anno di pubblicazione: 2016
  • Tipologia: Articolo in rivista
  • OA Link:


Mediterranean spotted fever (MSF) is an infectious disease endemic in the southern regions of Italy, with an incidence of about 400 cases/year. The bacteria responsible of the disease is Rickettsia conorii, transmitted to humans by Rhipicephalus sanguineus, the common dog tick. The infection usually manifests with a characteristic symptomatologic triad: fever, exanthema and the so called tache noire, which is the typical eschar at the site of the tick bite. Immunoglobulin M (IgM) and IgG enzymelinked immunosorbent assay and the gold standard micro-immunofluorescent assay, allow serological diagnosis. We report the case of a man suffering from MSF, whose atypical presentation and false-negative diagnostic tests delayed consistently diagnosis and therapy. Afterwards we review the literature about this topic.