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ALICE CONIGLIARO

SENP1 activity sustains cancer stem cell in hypoxic HCC

  • Authors: Conigliaro, A.; Tripodi, M.; Parola, M.
  • Publication year: 2017
  • Type: Recensione in rivista (Recensione in rivista)
  • Key words: HEPATOCELLULAR CARCINOMA; MOLECULAR CARCINOGENESIS; STEM CELLS
  • OA Link: http://hdl.handle.net/10447/241665

Abstract

Hepatocellular carcinoma (HCC) represents the fifth most common cancer and the third leading cause of cancer mortality worldwide, with a minority of patients surviving at 5 years from diagnosis, despite treatment. HCC usually develops in conditions of chronic liver disease (CLD), mostly on the background of a cirrhotic liver, with liver transplantation at present being the only treatment strategy to cure both HCC and the specific CLD.