SYNTHESIS AND EVALUATION OF CURCUMIN ANALOGUES AS NEURO-PROTECTIVE AGENTS FOR THE ALZHEIMER'S DISEASE
- Autori: Giacalone, V; Accardo, A; Martorana, A; Lauria, A; Almerico, AM; Buscemi, S; Palumbo Piccionello, A
- Anno di pubblicazione: 2013
- Tipologia: eedings
- Parole Chiave: Alzheimer's Disease, curcumin, curcumin-like compounds, amyloid peptide
- OA Link: http://hdl.handle.net/10447/96982
Abstract
The Alzheimer's disease (AD) is the most common form of senile dementia.1 The most important role in AD is played by the aggregation process of beta-amyloid peptide (Aß), responsible for the cytotoxic effects.2 In this context, the purpose of this study was to synthesize new dicarbonyl compounds 1 structurally related to curcumin3, with anti-aggregation activity against Aß.Parallel studies involve the synthesis of heterocyclic-based curcumin-like molecules that are currently under investigation by means of in silico protocols in order to rationalize the ligand-biological target interactions.