Cytotoxic activity of some natural and synthetic kauranes
- Autori: ROSSELLI S; BRUNO M; MAGGIO A; BELLONE G; CHEN T H; BASTOW K F LEE K H
- Anno di pubblicazione: 2007
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: ANTITUMOR AGENTS; DERIVATIVES
- OA Link: http://hdl.handle.net/10447/5118
Abstract
Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 mu M, respectively. These two 1-analogues are promising lead compounds for further investigation.