Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)
- Autori: Autore, G.; Marzocco, S.; Formisano, C.; Bruno, M.; Rosselli, S.; Jemia, M.; Senatore, F.
- Anno di pubblicazione: 2015
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Bergaptene; Coumarins; Furanocoumarins; Isopimpinellin; Magydaris tomentosa; MCF-7; Osthole; Xanthotoxin; Xanthotoxol;
- OA Link: http://hdl.handle.net/10447/253291
Abstract
The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.