Diet and Immunosenescence
- Autori: Accardi, G.; Balistreri, C.; Caruso, C.; Candore, G.
- Anno di pubblicazione: 2014
- Tipologia: Capitolo o Saggio (Capitolo o saggio)
- OA Link: http://hdl.handle.net/10447/93523
Ageing is a systemic condition leading to a gradual loss of molecular and cellular fidelity. A feature of ageing is immunosenescence, consisting of several modifications that increase morbidity and mortality in elderly. Environment, genetic background, immune system, and intestinal microbiota play a fundamental role in immunosenescence. The development of a chronic, low-grade, inflammatory status, known as “inflamm-ageing,” is a typical aspect of immunosenescence mostly due to the pro-inflammatory cytokine production linked to the chronic antigenic load. Nutrition can act on ageing, immunity, and health in general. Unbalanced diet with an insufficient intake of micro- and macronutrient and vitamins is a major nutritional problem among elderly, resulting in a dramatic change in gut microbiota. Calorie restriction and long-term adherence to Mediterranean diet could prevent or manage agerelated diseases and immunosenescence.