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Diet and Immunosenescence

  • Autori: Accardi, G.; Balistreri, C.; Caruso, C.; Candore, G.
  • Anno di pubblicazione: 2014
  • Tipologia: Capitolo o Saggio (Capitolo o saggio)
  • OA Link:


Ageing is a systemic condition leading to a gradual loss of molecular and cellular fidelity. A feature of ageing is immunosenescence, consisting of several modifications that increase morbidity and mortality in elderly. Environment, genetic background, immune system, and intestinal microbiota play a fundamental role in immunosenescence. The development of a chronic, low-grade, inflammatory status, known as “inflamm-ageing,” is a typical aspect of immunosenescence mostly due to the pro-inflammatory cytokine production linked to the chronic antigenic load. Nutrition can act on ageing, immunity, and health in general. Unbalanced diet with an insufficient intake of micro- and macronutrient and vitamins is a major nutritional problem among elderly, resulting in a dramatic change in gut microbiota. Calorie restriction and long-term adherence to Mediterranean diet could prevent or manage agerelated diseases and immunosenescence.