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LUISA AGNELLO

Vitamin K deficiency bleeding leading to a diagnosis of Crohn’s Disease

  • Autori: Agnello, L; Bellia, C; Lo Coco, L; Vitale, S; Coraci, F; Bonura, F; Gnoffo, R; Napolitano, M; Caruso, A; Bivona, G; Lo Sasso, B; Ciaccio, M
  • Anno di pubblicazione: 2014
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/98445

Abstract

We report the case of a 45 year old man who came to Emergency Room of Polyclinic for sudden onset of localized ecchymosis and widespread hematomas. He was subjected to blood count and first level investigations to assess coagulation. Based on the results, second level investigations were performed. Endoscopy of the gastrointestinal tract with histological examination revealed a diagnosis of Crohn's disease. Vitamin K deficiency causes the formation of vitamin K-dependent clotting factors that cannot perform their pro-coagulant action. Consequently, patients present with hemorrhagic manifestations. Clinical and laboratory features observed in this patient show that the deficiency of vitamin K-dependent coagulation factors may reveal a complex clinical condition such as an inflammatory bowel disease.