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LUIGI AUGUGLIARO

Genetic Network construction in CML gene expression profile data analysis

  • Authors: Augugliaro, L; Mineo, A; Cammarata, G; Santoro, A
  • Publication year: 2009
  • Type: eedings
  • Key words: Gaussian graphical models, modularity, differentially expressed genes.
  • OA Link: http://hdl.handle.net/10447/44266

Abstract

Aim of this paper is to define a new statistical framework to identify central modules in Gaussian Graphical Models (GGMs) estimated by gene expression data measured on a sample of patients with negative molecular response to imatinib. A central module is defined as a module of a GGM which contains genes that are defined differentially expressed.