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FRANCESCO VITALE

A Multiplex Panel of Plasma Markers of Immunity and Inflammation in Classical Kaposi Sarcoma

  • Autori: Aka, P.; Kemp, T.; Rabkin, C.; Shiels, M.; Polizzotto, M.; Lauria, C.; Vitale, F.; Pinto, L.; Goedert, J.
  • Anno di pubblicazione: 2014
  • Tipologia: Articolo in rivista (Articolo in rivista)

Abstract

Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we compared plasma from 15 human immunodeficiency virus (HIV)-negative classic KS cases to plasma from 29 matched controls, using a multiplex panel of immunity markers. Of 70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were strongly and significantly associated with KS, after adjustment for age and smoking status. These and previous observations are consistent with a tumor-promoting role for these cytokines, particularly CXCL10, but the small sample size and case-control design preclude firm conclusions on KS risk or pathogenesis. Larger,well-designed prospective studies are needed to better assess the association of these markers with KS.

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